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Pseudopterosin A : ウィキペディア英語版 | Pseudopterosin A
Pseudopterosin A is a diterpene glycoside isolated from the gorgian sea whip ''Pseudopterogorgia elisabethae'', found in the Bahamas and Florida Keys. 〔A. Kohl, A. Ata, R. Kerr. ''J. Ind Microbiol Biotechnol'' (2003) 30: 495-499.〕 Pseudopterosins A-D, which differ in the degree of acetylation at the sugar ring, were first isolated and reported in 1986.〔S. Look, W. Fenical, G. Matsumoto and J. Clardy. ''J. Org. Chem'' (1986) 51: 5140-5145〕 There are at least 25 unique diterpenes isolated from this species of marine animal.〔 Samples of ''P. elisabethae'' from the Bahamas are found to have higher concentrations of pseudopterosins than populations from the Florida Keys, which have a greater diversity in diterpene structures.〔A. Kohl and R. Kerr. ''Mar. Drugs'' (2003) 1: 54-65.〕 ==Uses== Pseudopterosins have anti-inflammatory and analgesic activity, with a mechanism of action different from the common non-steroidal anti-inflammatory drugs, NSAIDs.〔A. Kohl, R. Kerr. ''Arch. of Biochem. and Biophys.'' (2004) 424: 97-104.〕 Commercially, pseudopterosins are found in skin creams as topical anti-inflammatory agents.〔A. Mayer, P. Jacobson, W. Fenical, R. Jabocs and K. Glaser. ''Life Sciences'' (1998) 62: 401-407.〕
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